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尽管现在为核酸疫苗制定生产规程为时尚早.但是围绕一种新生物治疗剂使用问题的讨论永远不会赚早.核酸疫苗接种引起的主要安全性问国包括,在DNA疫苗接种者中出现转化(或致瘤)的可能性,可能形成抗DNA抗体以及长期表达一种外原抗原所产生的意外的不良后果.本文检查了这些问题影响ONA疫苗安全性的程度.
Although it is too early to formulate manufacturing protocols for nucleic acid vaccines, discussions around the use of a new biotherapeutic agent will never make any headaches. The main safety concerns raised by nucleic acid vaccination include transformation in DNA vaccinees (Or tumorigenicity) may result in unexpected adverse consequences of anti-DNA antibodies and long-term expression of an exogenous antigen.The paper examines the extent to which these issues affect the safety of the ONA vaccine.