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目的:通过对药源性血尿的不良反应报告分析,探讨药品引起血尿的特点及一般规律。方法:收集2004-2012年河南省药品不良反应数据库中引起血尿的不良反应病例报告,采用回顾性研究的方法,对影响药源性血尿的因素进行统计和分析。结果:药源性血尿患者以60岁以上的老年患者发生几率最大,为19.42%;引起血尿的药品以抗微生物药、解热镇痛抗炎药为主,分别为总数的51.26%、18.45%。结论:安全、合理地使用药品,研究和避免血尿的诱发因素,对减少不良反应的发生有重要的临床意义。
Objective: Through the analysis of adverse reactions of drug-induced hematuria, we discuss the characteristics and general rules of hematuria caused by drugs. Methods: The adverse reactions of hematuria in Henan ADR database collected from 2004 to 2012 were collected and analyzed retrospectively. The influencing factors of drug-induced hematuria were statistically analyzed. Results: The incidence of drug-induced hematuria in elderly patients over the age of 60 was the highest, accounting for 19.42%. The anti-microbial drugs and anti-pyretic analgesic and anti-inflammatory drugs were the main drugs causing hematuria, accounting for 51.26% and 18.45% . Conclusion: The safe and rational use of drugs to study and avoid hematuria induced factors, to reduce the incidence of adverse reactions have important clinical significance.