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目的探讨止痛化症片应用于异位妊娠保守治疗的有效性和安全性。方法选取2012年4月-2015年3月就诊于无锡市妇幼保健院妇科的126例异位妊娠患者,随机分为对照组和观察组,每组各63例。对照组患者给予甲氨蝶呤联合米非司酮片治疗;观察组患者加用止痛化症片,连续治疗7 d。评价治疗的临床效果,监测治疗前后血清β-h CG水平变化、盆腔包块大小及盆腔积液深度变化,记录血清β-h CG恢复正常时间及盆腔包块消失时间,观察临床诊治的安全性。结果对照组患者的临床有效率为81.0%,观察组为95.2%,两组比较,差异有统计学意义(P<0.05);观察组患者血清β-h CG水平下降、盆腔包块缩小及盆腔积液减少程度较对照组更为明显,血清β-h CG恢复正常时间、盆腔包块消失时间明显短于对照组,两组比较,差异有统计学意义(P<0.05);观察组患者的不良反应发生率为7.9%,对照组为22.2%,两组比较,差异有统计学意义(P<0.05)。结论止痛化症片应用于异位妊娠保守治疗有效性和安全性高,值得临床推广运用。
Objective To investigate the efficacy and safety of analgesic syndromes in the conservative treatment of ectopic pregnancy. Methods 126 cases of ectopic pregnancy in gynecology of Wuxi Maternal and Child Health Hospital from April 2012 to March 2015 were randomly divided into control group and observation group with 63 cases in each group. Patients in the control group were given methotrexate combined with mifepristone tablets. Patients in the observation group were treated with pain-relieving tablets for 7 days. The clinical effect of treatment was evaluated. The change of serum β-h CG level, pelvic mass size and pelvic fluid depth before and after treatment were monitored. The time of recovery of serum β-h CG and disappearance of pelvic mass were recorded, and the safety of clinical diagnosis and treatment . Results The clinical effective rate was 81.0% in the control group and 95.2% in the observation group. There was significant difference between the two groups (P <0.05). The serum level of β-h CG decreased, pelvic mass shrinkage and pelvic cavity The reduction of effusion was more obvious than that of the control group. Serum β-h CG returned to normal time and the disappearance time of pelvic mass was significantly shorter than that of the control group. There was significant difference between the two groups (P <0.05) The incidence of adverse reactions was 7.9% in the control group and 22.2% in the control group. There was significant difference between the two groups (P <0.05). Conclusion The analgesic tablet is effective and safe for conservative treatment of ectopic pregnancy, and is worthy of clinical application.