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目的探讨不同药物方案对高血压患者疗效的影响。方法选取我院2016年2月~2016年12月收治的高血压患者120例作为研究对象,随机分为三个治疗组,各40例,分别为临床A组、临床B组和临床C组。对临床A组应用苯磺酸氨氯地平片药物治疗,对临床B组应用缬沙坦药物治疗,对临床C组应用缬沙坦氨氯地平片药物治疗。观察三小组患者治疗前后的血压平均改变情况及用药后不良反应。结果用药治疗后,临床C组患者的平均舒张压及收缩压均低于临床A组与临床B组,差异有统计学意义(P<0.05);而且临床C组用药后不良反应的比率为2.5%(1/40),均低于临床A组的12.5%(5/40)与临床B组的10%(4/40),差异有统计学意义(P<0.05)。结论通过对不同药物方案对高血压患者疗效的影响观察,发现缬沙坦氨氯地平片较苯磺酸氨氯地平片及缬沙坦的药物疗效更优,且具有很好的应用安全性,值得在临床用药治疗高血压疾病时优先选择应用。
Objective To investigate the effect of different drug regimens on the therapeutic effect of hypertension. Methods A total of 120 hypertensive patients admitted from February 2016 to December 2016 in our hospital were selected as study subjects and randomly divided into three treatment groups, 40 cases each, which were clinical A group, clinical B group and clinical C group. A clinical application of amlodipine besylate tablets drug treatment, the clinical application of valsartan group B drug treatment, clinical C group valsartan amlodipine drug treatment. Three groups of patients before and after treatment to observe the average change in blood pressure and adverse drug reactions. Results After treatment, the average diastolic blood pressure and systolic blood pressure of patients in clinical group C were lower than those in clinical group A and clinical group B (P <0.05), and the ratio of adverse reactions in clinical group C was 2.5 % (1/40), respectively, which were lower than 12.5% (5/40) in clinical group A and 10% (4/40) in clinical group B, the difference was statistically significant (P <0.05). Conclusion Through the observation of the effect of different drug regimens on the patients with hypertension, we found that valsartan amlodipine is better than amlodipine besylate tablets and valsartan, and has good application safety, Worth in the clinical medication for the treatment of hypertension preferred to use.