Simultaneous acquisition of multi-nuclei enhanced NMR/MRI by solution-state dynamic nuclear polariza

• 作 者: Yugui He Zhen Zhang Jiwen Feng Chongyang Huang Fang Chen Chaoyang Liu Maili Liu
• 机 构: State Key Laboratory of Magnet Resonance and Atomic and Molecular Physics, Wuhan Institute of Physic
• 出 处: Science China(Chemistry)
• 发表日期: 2016年07期
• 关键词: nuclei simultaneous superiority capable enhancing have dramatically

Dynamic nuclear polarization(DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance(NMR) of various molecules.Liquid-state DNP based on Overhauser effect is capable of directly enhancing polarization of all kinds of nuclei in the system.The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides a variety of important applications in both MR spectroscopy(MRS) and image(MRI).Here we present two simple illustrative examples for simultaneously enhanced multi-nuclear spectra and images to demonstrate the principle and superiority.We have observed very large simultaneous DNP enhancements for different nuclei,such as ~1H and ~(23)Na,~1H and ~(31)P,~(19)F and ~(31)P,especially for the first time to report sodium ion enhancement in liquid.We have also obtained the simultaneous images of ~(19)H and ~(31)P,~(19)F and ~(31)P at low field by solution-state DNP for the first time.

Dynamic nuclear polarization (DNP) has become a very important hyperpolarization method because it can dramatically increase the sensitivity of nuclear magnetic resonance (NMR) of various molecules. Liquid-state DNP based on Overhauser effect is capable of directly conductivizing polarization of all kinds of nuclei in the system. The combination of simultaneous Overhauser multi-nuclei enhancements with the multi-nuclei parallel acquisitions provide a variety of important applications in both MR spectroscopy (MRS) and image (MRI). Here we present two simple examples examples for simultaneously enhanced multi -nuclear spectra and images to demonstrate the principle and superiority. We have observed very large DNP enhancements for different nuclei, such as ~ 1H and ~ (23) Na, ~ 1H and ~ (31) P, ~ (19) F and ~ (31) P, especially for the first time to report sodium ion enhancement in liquid. We have also obtained the equivalent images of ~ (19) H and ~ (31) P, ~ (19) F and ~ (31) P at low field by solution-s tate DNP for the first time.