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目的了解广东省惠州地区流动人口育龄妇女人乳头瘤病毒(human papillomavirus,HPV)感染、分型及宫颈病变的现况,分析感染、HPV型别与宫颈病变程度的关系。方法对7 796例已婚育龄妇女进行HPV-DNA检测和分型,对HPV阳性者进行宫颈液基薄层细胞学(thinprep cytology test,TCT)检测,对检测结果进行分析。结果 7 796例受检对象中共检出HPV感染568例(7.29%),以HPV16、58、52、18型多见。25岁以下女性HPV感染阳性率最高(15.97%),高于其他年龄组(P<0.05)。对568例HPV感染者进行TCT筛查,ASCUS级以上宫颈病变298例(52.46%)。结论广东省惠州地区流动人口育龄妇女HPV感染主要感染类型为HPV16、58、52、18型,感染者年龄以15~24岁人群最高,宫颈病变发生率及病变程度随感染者年龄增加而升高。定期筛查HPV感染,尤其高龄感染者是早期发现宫颈病变和预防宫颈癌的重要手段。
Objective To investigate the status of human papillomavirus (HPV) infection, typing and cervical lesions in migrant women of childbearing age in Huizhou, Guangdong Province, and to analyze the relationship between infection, HPV type and the severity of cervical lesions. Methods HPV DNA was detected and classified in 7 796 married women of childbearing age. Thinprep cytology test (TCT) was performed on HPV-positive women. The results of the detection were analyzed. Results A total of 568 cases (7.29%) of HPV infections were detected in 7 796 subjects, most of which were HPV16, 58, 52 and 18 types. The highest positive rate of HPV infection was found in women under 25 years old (15.97%), higher than other age groups (P <0.05). TCT screening was performed on 568 cases of HPV infection, 298 cases of cervical lesions above ASCUS (52.46%). Conclusions The main types of HPV infection among women of childbearing age in migrant population in Huizhou, Guangdong Province are HPV16, HPV58, HPV52 and HPV18. The age of infected persons is the highest among those aged 15-24 years. The incidence of cervical lesions and the severity of cervical lesions increase with age . Regular screening for HPV infection, especially in elderly patients is an early detection of cervical lesions and prevention of cervical cancer is an important means.