抗病毒药物对CHB病人离体培养外周血淋巴细胞的遗传学影响

• 作 者: 王培林 丛书英 陈在春 张峰 张超英 韩宏志
• 机 构: 青岛市传染病医院，第二炮兵青岛疗养院
• 出 处: 青岛医学院学报
• 发表日期: 1995年03期
• 关键词: 抗病毒药物 CHB 外周血淋巴细胞 平均频率 染色体脆性 体外诱导 乙型肝炎 慢性活动性 脆性位点 白细胞干扰素

应用３种不同抗乙型肝炎病毒药物，以单独和联合用药的方式，离体处理慢性乙型肝炎（ＣＨＢ）病人外周血淋巴细胞（ＰＢＬ），分别观察姊妹染色单体交换（ＳＣＥ）平均频率、脆性位点（ＦＳ）和ＨＢＶ标记物（ＨＶＢＭ）等多项实验指标。结果表明，９个实验组均能显著地降低ＣＨＢ病人ＰＢＬ－ＳＣＥ频率，具有显著的ＨＢｅＡｇ，ＨＢＶ－ＤＮＡ的阴转率和ＡＬＴ的复常率，说明人白细胞干扰素等３种抗病毒药物均具有体外诱导ＣＨＢ病人ＤＮＡ损伤的修复作用。染色体核型中第１，２，３号染色体可能易受ＨＢＶ的侵袭。

Three different anti-HBV drugs were used to treat peripheral blood lymphocytes (PBL) in chronic hepatitis B (CHB) patients separately and in combination. The average frequency of sister chromatid exchange (SCE) , Brittle loci (FS) and HBV markers (HVBM) and many other experimental indicators. The results showed that the nine experimental groups could significantly reduce the frequency of PBL-SCE in patients with CHB, with significant HBeAg, HBV-DNA negative conversion rate and ALT normalization rate, indicating that human leukocyte interferon and other three antiviral drugs are It can repair DNA damage induced by CHB in vitro. Chromosome karyotype 1, 2, 3 chromosome may be susceptible to HBV invasion.