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目的了解黏糖蛋白-2(MUC-2)和组织蛋白酶-D(Cath-D)在大肠癌中的表达。方法免疫组织化学S-P法,检测60例大肠癌中MUC 2和Cath-D的表达情况。结果 MUC-2在大肠癌中的阳性率为70．00％,它的低表达与大肠癌的分期、分化程度和肠外转移呈正相关而与患者的性别、年龄、肿瘤的大体类型和淋巴转移与否等无关。Cath-D在大肠癌中的阳性率为66．67％,它的高表达与大肠癌的淋巴转移和肠外转移呈正相关而与患者的性别、年龄、肿瘤的大体类型、分期和分化程度等无关。结论 MUC-2和Cath-D的检测可成为大肠痛的恶性程度和肠外转移与否的重要参考指标。
Objective To investigate the expression of MUC-2 and Cath-D in colorectal carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of MUC 2 and Cath-D in 60 cases of colorectal cancer. Results The positive rate of MUC-2 in colorectal cancer was 70.00%. The low expression of MUC-2 was positively correlated with the staging, differentiation and parenteral metastasis of colorectal cancer, but not with the gender, age, general type of tumor and lymphatic metastasis It has nothing to do with whether or not. The positive rate of Cath-D in colorectal cancer was 66.67%. The positive expression of Cath-D was positively correlated with lymphatic metastasis and extraintestinal metastasis of colorectal cancer, but not with the gender, age, general type of tumor, staging and differentiation Nothing to do Conclusion The detection of MUC-2 and Cath-D may become the important reference index of malignant degree and metastasis of colorectal cancer.