逆向疫苗学及其研究进展

• 作 者: 张兆山
• 机 构: 军事医学科学院生物工程研究所 北京100071
• 出 处: 军事医学科学院院刊
• 发表日期: 2004年03期
• 关键词: 基因组 疫苗 逆向疫苗学

基于基因组的疫苗研发途径被称为逆向疫苗学 ,它不仅省时、经济 ,而且可为传统方法难于或根本无法开展的疫苗研究提供新的解决方法。逆向疫苗学的研究过程始于硅片 ,用计算机预测疫苗的所有抗原 ,不依赖于抗原是否丰富 ,也不需要微生物是否能够体外培养。本文介绍逆向疫苗学的概况 ,特别是近年来在研制某些病原菌新疫苗方面的进展。

The genomic-based approach to vaccine development is called reverse vaccination, which is not only time-saving and economical but also offers new solutions to vaccine research that is difficult or impossible with traditional methods. The reverse vaccination process starts with silicon and uses computers to predict all the antigens of the vaccine independent of whether the antigen is abundant or not and whether or not the microorganism can be cultured in vitro. This article describes the general situation of reverse vaccines, especially in recent years in the development of some new pathogens vaccine progress.