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应用体外培养细胞法和单细胞阳离子测定系统研究了稀土Ｌａ￣（３＋）与巨噬细胞的作用。实验结果表明，在培养介质中ＬａＣｌ＿３的浓度高子２ｍｍｏｌ·ｄｍ￣（－３）时，有明显的细胞毒性。配合物Ｌａ（Ａｌａ）＿３Ｃｌ＿３的细胞毒性小于ＬａＣｌ＿３。Ｌａ￣（３＋）对细胞膜上的Ｃａ￣（２＋）通道存在抑制作用，使细胞内游离Ｃａ￣（２＋）浓度发生变化。Ｌａ￣（３＋）对细胞膜Ｃａ￣（２＋）－ＡＴＰ酶有激活作用。
The effects of rare earth La ~ (3+) and macrophages were investigated by in vitro cell culture and single cell cation assay. The experimental results show that there is obvious cytotoxicity when the concentration of LaCl_3 in culture medium is 2 mmol · dm ~ (-3) high. The cytotoxicity of La (Ala) _3Cl_3 is less than that of LaCl_3. La ~ (3+) inhibits the Ca 2+ channel on the cell membrane and changes the intracellular free Ca ~ (2+) concentration. La ~ (3+) has an activating effect on Ca ~ (2 +) - ATPase.