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近来许多研究表明一些原癌基因的突变或重排常在甲状腺癌中出现。其中原癌基因RET和TRK的酪氨酸蛋白激酶活性与甲状腺乳头状癌的发病有特殊关系;RET基因的胚系突变,尤其是密码子634的突变可引起多发性内分泌腺瘤综合征Ⅱa和家族性甲状腺髓样癌;甲状腺转录因子.过氧化物酶体增殖物激活受体γ1(PAX8-PPARγ1)融合蛋白可促进不同的甲状腺滤泡腺瘤形成,常在滤泡癌中发现。
Recently, many studies have shown that some protooncogene mutations or rearrangements often appear in thyroid cancer. The proto-oncogene RET and TRK tyrosine kinase activity and thyroid papillary carcinoma of the disease has a special relationship; RET gene germline mutations, in particular codon 634 mutations can cause multiple endocrine neoplasia syndrome Ⅱ a and Familial thyroid medullary carcinoma, thyroid transcription factor, peroxisome proliferator-activated receptor γ1 (PAX8-PPARγ1) fusion protein can promote the formation of different thyroid follicular adenomas, often found in follicular carcinoma.