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目的 观察蛛网膜下腔出血（ＳＡＨ） 时血小板活化因子（ＰＡＦ） 的变化及其临床意义。方法 用高效薄层层析法对１６ 例ＳＡＨ 患者发病后第一、第二及第三周时脑脊液及发病后３ 天血浆中ＰＡＦ进行检测， 并与１０ 例对照组进行比较。结果 蛛网膜下腔出血组与对照组血浆ＰＡＦ含量比较无显著性差异（Ｐ＞ ０．０５），对照组脑脊液ＰＡＦ均为阴性，而ＳＡＨ 后第一周脑脊液中ＰＡＦ即呈阳性， 第二周含量最高， 第三周时有下降趋势。结论 ＰＡＦ可能与ＳＡＨ患者脑血管痉挛、脑缺血的发病过程有关。
Objective To observe the changes of platelet activating factor (PAF) in patients with subarachnoid hemorrhage (SAH) and its clinical significance. Methods The plasma levels of PAF in cerebrospinal fluid (CSF) and 3 days after onset of symptoms in 16 patients with SAH were detected by high performance thin layer chromatography and compared with 10 control subjects. Results There was no significant difference in plasma PAF content between subarachnoid hemorrhage group and control group (P> 0.05), while PAF in control group was negative, while PAF was positive in cerebrospinal fluid in the first week after SAH. In the second week The highest content, the third week when there is a downward trend. Conclusions PAF may be related to the pathogenesis of cerebral vasospasm and cerebral ischemia in patients with SAH.