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目的观察轻中度原发性高血压合并单纯高尿酸血症患者应用坎地沙坦治疗前后血尿酸、24h尿尿酸、尿酸清除率的变化。方法选择河北大学附属医院近16个月轻中度原发性高血压合并单纯高尿酸血症患者79例;受试者研究期间均为低嘌呤膳食,并设定食谱,饮水量2000mL/d,连续14d后,服用坎地沙坦治疗21d,测定治疗前后受试者血尿酸、24h尿尿酸,计算尿酸清除率和校正尿酸清除率(尿量为2000mL标准的情况下计算得到的尿酸清除率)。结果服用坎地沙坦21d后,患者血压水平下降[平均动脉压:治疗前(115.4±8.6)比治疗后(98.0±6.6)mm Hg,P<0.01],血尿酸水平与治疗前比较,差异无统计学意义[治疗前(531.92±77.55)比治疗后(529.31±83.05)μmol/L,P=0.539],校正尿酸清除率与治疗前比较差异无统计学意义[治疗前(14.16±2.35)比治疗后(14.31±2.50)mL/min,P=0.591]。结论坎地沙坦降低平均动脉压,对血尿酸、尿酸清除率无影响。
Objective To observe the changes of serum uric acid, 24h uric acid and uric acid clearance before and after candesartan treatment in patients with mild to moderate essential hypertension complicated with hyperuricemia. Methods A total of 79 patients with mild-to-moderate essential hypertension and simple hyperuricemia were enrolled in Affiliated Hospital of Hebei University during the past 16 months. The subjects were all low-purine diet during the study period, After 14 days of continuous treatment with candesartan for 21 days, the serum uric acid and 24h uric acid were measured in subjects before and after treatment, the uric acid clearance rate and the uric acid clearance rate were calculated (urine uric acid clearance was calculated with urine volume being 2000mL) . Results After treatment with candesartan for 21 days, the blood pressure decreased (mean arterial pressure: 115.4 ± 8.6 before treatment (98.0 ± 6.6) mm Hg, P <0.01], and the level of serum uric acid was significantly lower than that before treatment There was no significant difference between before and after treatment (531.92 ± 77.55 vs 529.31 ± 83.05 μmol / L, P = 0.539). There was no significant difference in corrected uric acid clearance before treatment (14.16 ± 2.35) Than after treatment (14.31 ± 2.50) mL / min, P = 0.591]. Conclusions Candesartan can reduce mean arterial pressure and have no effect on serum uric acid and uric acid clearance rate.