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近来的研究报道指出接受降压治疗的患者,其长时血压变异性有独立的预后意义。有报道称与用钙拮抗剂或其他种类药物相比,用β受体阻滞剂治疗的患者长时血压变异性较大。该研究旨在探索参与欧洲拉西地平治疗动脉粥样硬化研究的高血压患者,服用拉西地平或阿替洛尔治疗4年后,其个体诊室血压和24h平均血压的长时血压差异性;并探讨在治疗过程中评估β受体阻滞剂和钙拮抗剂不同治疗效果时,诊室和24h血压的个体间差异是否能作为患者个体血压变异性的替代指标。
Recent studies have reported that patients receiving antihypertensive therapy have long-term variability of independent prognostic significance. It has been reported that patients treated with β-blockers have long-term variability in blood pressure variability compared with calcium antagonists or other types of drugs. The aim of this study was to explore the long-term blood pressure variability of individual clinic blood pressure and 24h mean blood pressure after 4 years of lacidipine or atenolol treatment in patients with hypertension who participated in the study of atherosclerosis in lacridin in Europe; And to explore whether intra-clinic and inter-individual differences in 24-h blood pressure can be used as surrogate markers for individual BP variability when assessing different treatment effects of beta-blockers and calcium antagonists during treatment.