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目的研究钙通道阻滞剂硝苯啶（ＮＦＰ）长期口服对３２例肝硬变门脉高压患者肝血流及肝功的影响．方法采用无创伤性核多功能仪首次通过法观察肝血流，同时记录服药前后体循环及肝功等变化．结果ＮＦＰ口服４周以上，总体患者及Ｃｈｉｌｄ＿Ｐｕｇｈ分级的各级患者均显示可明显减少门脉血流（ｋｖ），使肝动脉血流（ｋａ）增加，而不影响肝脏的总血流（ｋａ＋ｋｖ）；对平均动脉压（ＭＡＰ）及心率（ＨＲ）等体循环的影响甚小，并可改善血清白蛋白、胆红素及ＡＬＴ水平．结论ＮＦＰ可长期用于临床降低肝硬变门脉高压，预防食管曲张静脉破裂出血
Objective To study the effect of long-term oral administration of calcium channel blocker nifedipine (NFP) on liver blood flow and liver function in 32 patients with cirrhosis and portal hypertension. Methods The noninvasive nuclear multi-function instrument was used to observe the hepatic blood flow for the first time. At the same time, changes of systemic circulation and liver function were recorded before and after treatment. Results Oral administration of NFP for more than four weeks showed that all patients at all levels and Child_Pugh grading significantly reduced portal blood flow (kv) and increased hepatic artery blood flow (ka) without affecting hepatic total blood flow (ka + kv) ; On the average arterial pressure (MAP) and heart rate (HR) and other systemic circulation has little effect, and can improve serum albumin, bilirubin and ALT levels. Conclusion NFP can be used for a long time to reduce the portal hypertension of cirrhosis and prevent the bleeding of esophageal varices