论文部分内容阅读
目的 探讨硫酸镁、脑复素(含bFGF)、高压氧(HBO)对新生儿缺氧缺血性脑病(HIE)的治疗作用。方法 用硫酸镁、脑复素、HBO治疗HIE 66例,同时设胞二磷胆碱对照组60例,两组均给予三项支持、两项对症治疗。观察治疗前后血清一氧化氮(NO)和丙二醛(MDA)的水平、脑CT的改变、NBNA评分以评价疗效。结果 观察组治疗后NO、MDA水平、脑CT、NBNA评分结果均明显优于对照组,各项指标经统计学处理两组差异有显著性意义(P<0.05)。结论 硫酸镁、脑复素、HBO治疗HIE有明显疗效。
Objective To investigate the therapeutic effects of magnesium sulfate, norepinephrine (including bFGF) and hyperbaric oxygen (HBO) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty-six patients with HIE were treated with magnesium sulfate, norepinephrine and HBO, and 60 citicoline control group were given. The two groups were given three support and two symptomatic treatment. The levels of serum nitric oxide (NO) and malondialdehyde (MDA), brain CT changes and NBNA score were observed before and after treatment to evaluate the curative effect. Results After treatment, NO and MDA levels, brain CT and NBNA scores in the observation group were significantly better than those in the control group. There was significant difference between the two groups (P <0.05). Conclusion Magnesium sulfate, norepinephrine, HBO treatment of HIE have a significant effect.