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目的 探讨儿童难治性肾病和小管间质损害之间的关系 ,更好地指导临床治疗 ,判断预后。方法观察难治性肾病小管间质损害的临床、病理特点 ,并对照激素敏感性肾病进行分析。结果 出现小管间质功能障碍临床表现的病例均在难治性肾病组 ,并且伴有较严重的小管间质病理损害 ;难治性肾病组病理类型以系膜增殖性肾炎为主 ,激素敏感组以微小病变性肾病为主 ,两组间在病理类型上有显著差异 ,两组间的年龄、病程、小管间质病理损害、β2 -MG有显著性差异 ;小管间质病理损害的程度与病理类型之间的关系无显著性差异。结论 肾小管间质病变程度可作为判断肾病综合征疗效、预后的指标。
Objective To explore the relationship between refractory renal disease and tubulointerstitial injury in children and to better guide the clinical treatment and prognosis. Methods To observe the clinical and pathological features of tubulointerstitial damage in refractory nephropathy, and to analyze the hormone-sensitive nephropathy. Results The clinical manifestations of tubulointerstitial dysfunction were all in refractory nephropathy group with more serious tubulointerstitial pathological changes. The pathological types of refractory nephropathy group were mesangial proliferative glomerulonephritis and hormone sensitive group The main lesion was nephropathy. There were significant differences in pathological types between the two groups. The age, course of disease, tubulointerstitial pathological lesions and β2-MG were significantly different between the two groups. The degree of tubulointerstitial lesions and pathology No significant difference between the type of relationship. Conclusion The degree of tubulointerstitial lesions can be used as an index to judge the efficacy and prognosis of nephrotic syndrome.