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对初次发病且发病后36h内收住冠心病监护室的43例急性心肌梗塞(AMI)患者,采用黄芪口服液治疗,进行了4周心功能的动态观察。研究表明,黄芪(60g/d)可使AMI患者药后射血前期/左室射血时间(PEP/LVET)比值显著下降,优于基础治疗组;同时提高AMI患者红细胞超氧化物歧化酶(SOD)活性,降低血浆过氧化脂质(LPO)含量,作用均优于基础治疗组;并证明了PEP/LVET比值与SOD活性、LPO含量的相关性。研究表明,黄芪抗氧自由基的作用可能是其强心作用机制之一。
Forty-three patients with acute myocardial infarction (AMI) who were admitted to the coronary care unit within 36 hours after the onset of the disease were treated with Huangqi Oral Liquid, and the cardiac function was observed dynamically for 4 weeks. Studies have shown that jaundice (60g/d) can significantly reduce the ratio of postoperative ejection/left ventricular ejection (PEP/LVET) after AMI in patients with AMI, which is better than that of the basic treatment group; meanwhile, erythrocyte superoxide dismutase (SOD) in AMI patients can be increased. The activity of SOD and the content of plasma lipid peroxidation (LPO) were lower than that of the basic treatment group. The correlation between the ratio of PEP/LVET and the activity of SOD and the content of LPO was proved. Studies have shown that the antioxidant effect of Radix Astragali may be one of its cardiotonic mechanisms.