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多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是以排卵稀发、无排卵,高雄激素血症及胰岛素抵抗为特征的内分泌、代谢紊乱症候群。胰岛素抵抗及其伴随的高胰岛素血症是PCOS患者重要的病理生理改变。由于胰岛素具有促进内膜细胞增殖,抑制内膜细胞凋亡,促进胰岛素样生长因子及血管内皮生长因子生成,促进黄体生成素释放激素及促黄体生成素生成及降低体内脂联素水平等作用,可能是PCOS患者罹患内膜癌的危险因素,故对PCOS患者胰岛素抵抗/高胰岛素血症与子宫内膜癌的关系进行探讨。
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic disorder characterized by sparse ovulation, anovulation, hyperandrogenism and insulin resistance. Insulin resistance and its accompanying hyperinsulinemia are important pathophysiological changes in PCOS. As insulin has the function of promoting the proliferation of endometrial cells, inhibiting the apoptosis of endometrial cells, promoting the production of insulin-like growth factor and vascular endothelial growth factor, promoting the production of luteinizing hormone-releasing hormone and luteinizing hormone and lowering adiponectin in vivo, May be PCOS patients suffering from endometrial cancer risk factors, so PCOS patients with insulin resistance / hyperinsulinemia and endometrial cancer were explored.