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目的 观察地塞米松灌注液对兔眼玻璃体切割术后眼内纤维蛋白渗出的影响。方法 青紫蓝兔 12只 (2 4只眼 )随机分为 3组 ,均进行标准的晶状体粉碎及玻璃体切割 ,术中盲法给予灌注液 ,3组灌注液分别为 :(1)地塞米松组 :平衡盐液中含地塞米松 0 .0 1g· L- 1 ;(2 )低分子量肝素组 :平衡盐液中含低分子量肝素 (速避凝 ) 6× 10 3IU· L- 1 ;(3)对照组 :平衡盐液中不加任何药物。结果 术后地塞米松组眼内纤维蛋白渗出与对照组相比无显著差异 (P>0 .0 5 ) ,仅低分子量肝素组于术后第 1天渗出较轻 ,并有显著性差异 (P<0 .0 0 1)。结论 玻璃体切割术中使用地塞米松灌注液并不能有效减轻玻璃体切割术后的眼内纤维蛋白渗出。
Objective To observe the effect of dexamethasone perfusion on intraocular fibrin exudation after vitrectomy in rabbit eyes. Methods 12 rabbits (24 eyes) were randomly divided into 3 groups. All of them were subjected to standard lens crush and vitrectomy. Intraperitoneal injection of perfusate was given by blinded intraperitoneal injection. The perfusion of the three groups were as follows: (1) Dexamethasone group : Balanced salt solution containing dexamethasone 0 .0 1g · L- 1; (2) low molecular weight heparin group: balanced salt solution containing low molecular weight heparin (contraception) 6 × 10 3IU · L- 1; (3 Control group: balanced salt solution without any drug. Results Intraocular fibrin exudation in the dexamethasone group was not significantly different from the control group (P> 0.05). Only the low-molecular-weight heparin group excreted less on the first postoperative day, with significant difference Difference (P <0. 0 0 1). Conclusion The use of dexamethasone perfusion in vitrectomy does not effectively reduce intraocular fibrin exudation after vitrectomy.