论文部分内容阅读
目的探讨Ki-67、PCNA和Survivin在胃肠道间质瘤(gastrointestinal stromal tumor,GIST)组织中的表达及其与GIST临床病理参数的关系。方法应用免疫组化SP法检测103例GIST组织中Ki-67、PCNA和Survivin的表达。结果 GIST组织中Ki-67、PCNA和Survivin阳性表达率分别为56.3%、68.0%、72.8%,Ki-67、PCNA和Sur-vivin表达与GIST的发生年龄、性别、部位、组织学类型无关,而与肿瘤的NIH分级有关,且Ki-67、PCNA与Survivin的表达呈显著性正相关。结论 Ki-67、PCNA和Survivin联合检测可作为判定GIST恶性程度及预后的重要指标。
Objective To investigate the expression of Ki-67, PCNA and Survivin in gastrointestinal stromal tumor (GIST) and their relationship with clinicopathological parameters of GIST. Methods The expressions of Ki-67, PCNA and Survivin in 103 cases of GIST were detected by immunohistochemical SP method. Results The positive rates of Ki-67, PCNA and Survivin in GIST tissues were 56.3%, 68.0%, 72.8% respectively. The expressions of Ki-67, PCNA and Survivin in GIST tissues were not related to the age, sex, location and histological type of GIST. But not related to the grade of NIH. The expression of Ki-67, PCNA and Survivin was significantly and positively correlated. Conclusion The combined detection of Ki-67, PCNA and Survivin can be used as an important index to judge the malignant degree and prognosis of GIST.