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目的评价华法林抗凝及阿司匹林抗栓治疗低卒中危险因素房颤的有效性和安全性。方法 81例低卒中危险因素房颤患者随机分为两组,用华法林治疗组40例,INR(国际标准比值)2.0～2.5,阿司匹林抗栓治疗组41例,比较两组均治疗结果。结果治疗组与对照组比较,脑栓塞的发生率无显著性差异,脑出血、大出血、死亡事件的发生率也无显著性差异。结论华法林抗凝及阿司匹林抗栓治疗的低卒中危险因素房颤均为有效和安全。
Objective To evaluate the efficacy and safety of warfarin anticoagulation and aspirin antithrombotic therapy in the treatment of atrial fibrillation in stroke risk factors. Methods A total of 81 patients with low stroke risk factors for atrial fibrillation were randomly divided into two groups: 40 in warfarin group, 2.0 to 2.5 in INR (international standard ratio) and 41 in aspirin antithrombotic group. The treatment outcome was compared between the two groups. Results Compared with the control group, there was no significant difference in the incidence of cerebral embolism between the treatment group and the control group. There was no significant difference in the incidence of cerebral hemorrhage, major bleeding and death. Conclusions Warfarin anticoagulation and aspirin antithrombotic therapy for stroke risk factors for atrial fibrillation are effective and safe.