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目的探讨介入性综合治疗在下肢动脉硬化闭塞症(Arteriosclerosis obliterans, ASO)中的临床疗效。材料和方法回顾性分析经数字血管造影（DSA）证实的下肢动脉硬化闭塞症患者21例，共29条肢体；所有病例均行术前下肢CTA或术中DSA检查，先了解血流动力学变化，再分别采用不同的介入治疗方法；总结分析患者介入治疗技术、临床疗效、并发症及随访情况。结果28条肢体均获技术成功，介入综合治疗的成功率为96.6%（28/29)，并发症发生率为13.8%（4/29），包括穿刺点局限性血肿2例，动脉穿孔2例，无死亡病例。术后，成功进行介入手术者患侧肢体缺血症状完全消失或明显改善，术后D S A造影示狭窄的血管复通，患侧肢体踝肱指数（A B I）明显升高（P＜0.05）。术后随访6个月，2例患者发生再狭窄并有明显患侧肢体缺血表现，经P T A解除，一期通畅率为92.9%（26/28），患侧肢体保全率为100%（28/28）。结论介入性综合治疗方法在下肢动脉硬化闭塞症的治疗中安全、有效且并发症少，值得在临床中推广。“,”Objective To evaluate the clinical value of interventional comprehensive therapy in arteriosclerosis obliterans (ASO). Methods The clinical data of 21 cases (29 limbs) with ASO were analyzed retrospectively; al the cases received DSA or CTA examination to investigate the hemodynamic changes before the operation. Different intervention therapies were performed based on the actual situation. Interventional therapeutic technique, clinical efficacy, complications and data of fol ow-up were analysised individual y. Results Al 28 limbs were successful y placed; success rate of interventional comprehensive therapy was 96.6% (28/29); the complication rate of interventional comprehensive therapy was 13.8% (4/29), including 2 cases of localized hematoma in puncture point and 2 cases of artery perforation. No deaths occurred. The symptoms were significantly improved in those patients who were successful y placed interventional comprehensive therapy after surgery; DSA carried out immediately after the procedure showed angiostenosis were excluded; ankle-brachial index of the trouble side bodyincreased significantly(P<0.05). After 6 months of surgery, there were 2 cases restenosis, which were excluded with PTA. The primary patency rate was 92.9%(26/28); The limb salvage rate was 100%(28/28). Conclusion Interventional comprehensive therapy for arteriosclerosis obliterans is handy, safe, effective and less syndrome; which is worthy of application and dissemination in clinic.