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The purpose of the current investigation is to examine the influence of different physical parameters on the entropy gene- ration. The entropy generation number due to heat transfer and fluid friction is formulated. The velocity and temperature distributions across the tube are presented along with pressure attributes. Exact analytical solution for velocity and temperature profile is obtained. It is found that the entropy generation number attains high values in the region close to the walls of the tube, while it falls to low values near the center of the tube.