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目的 了解灯盏花素注射液治疗抗结核药物性肝损的疗效。方法 60例肺结核患者在抗结核治疗过程中出现抗结核药物性肝损,且达到停药标准时,随机分为2组。治疗组30例每天用灯盏花素注射液30ml加入10％的葡萄糖溶液500ml中静脉滴注,对照组30例则以维生素C 2g替代灯盏花素注射液,疗程均为25～30d,以肝功能恢复到正常为治疗有效,观察两组的有效率,用x~2检验两者的差异显著性。结果 实验组治疗药物性肝损有效率83.3％,比对照组50％高(P<0.01)。结论灯盏花素注射液对肝损害有保护作用,用于治疗抗结核药物性肝损是有效的。
Objective To understand the efficacy of breviscapine injection in the treatment of anti-TB drug-induced liver damage. Methods Sixty patients with pulmonary tuberculosis developed anti-TB drug-induced liver damage during anti-tuberculosis treatment and were divided into two groups randomly. In the treatment group, 30 cases were treated with 30ml of breviscapine injection daily in 500ml of 10% glucose solution and 30 cases of control group were treated with vitamin C 2g instead of breviscapine injection. The course of treatment was 25-30 days. Return to normal for the treatment of effective, observe the two groups of effective, with x ~ 2 test the significance of the difference between the two. Results The effective rate of experimental hepatic injury was 83.3% in the experimental group, which was 50% higher than that in the control group (P <0.01). Conclusion Breviscapine Injection has a protective effect on liver damage, and is effective in treating anti-TB drug-induced liver damage.