论文部分内容阅读
目的:观察制霉菌素泡腾片联用乳酸杆菌活菌制剂与单纯使用制霉菌素泡腾片治疗妊娠合并阴道念珠菌病(VVC)的治疗作用,比较2种用药方案的疗效。方法:将200例妊娠期VVC患者随机分为2组,其中A组为制霉菌素泡腾片组(96例),B组为乳杆菌活菌联合制霉菌素片组(104例),比较2组有效率、复发率及妊娠结局。结果:A、B组有效率分别为93.75%、98.08%(P>0.05),复发率分别为26.04%、2.88%(P<0.01);B组早产及胎膜早破发生率分别为2.99%、4.48%,均低于A组的15.09%、18.87%(P<0.01)。结论:对妊娠期VVC,在应用抗真菌药物的前提下加用乳酸菌制剂进行阴道局部微生态环境调整的巩固治疗,有效率高、复发率低,并可改善妊娠结局。
Objective: To observe the therapeutic effect of nystatin effervescent tablet combined with live lactobacillus preparation and nystatin effervescent tablet in the treatment of vaginal candidiasis in pregnancy (VVC), and to compare the curative effect of the two kinds of drug regimens. Methods: Two hundred and seventy cases of VVC during pregnancy were randomly divided into two groups: group A was nystatin effervescent tablet group (96 cases), group B was Lactobacillus combined with nystatin tablet group (n = 104) Group efficiency, recurrence rate and pregnancy outcome. Results The effective rates of group A and group B were 93.75% and 98.08%, respectively (P> 0.05), the recurrence rates were 26.04% and 2.88% respectively (P <0.01). The incidences of premature labor and premature rupture of membranes in group B were 2.99% , 4.48% respectively, which were all lower than 15.09% and 18.87% in group A (P <0.01). Conclusion: For the treatment of VVC during pregnancy, adding lactic acid bacteria to the consolidation of vaginal local microecological environment under the premise of applying antifungal drugs has the advantages of high efficiency, low recurrence rate and improvement of pregnancy outcome.