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纽约Colgate大学F.S Kraly等最近报告,组织胺和胰岛素均可刺激饮水,这一作用可被组织胺受体(H_1或H_2)阻断剂所阻断。给大鼠皮下注射组织胺可明显地刺激饮水,并在1.25～20mg/kg剂量范围内呈剂量反应关系,产生最大饮水反应的组织胺剂量是20mg/kg。在注射组织胺前10分钟给大鼠腹腔注射组织胺H_1受体阻断剂dexbrompheniramine(DXB),可显著抑制20mg/kg组织胺刺激的饮水(P<0.001)。在DXB2～16mg/kg范围内,随剂量加大,抑制作用加强。16mg/kg的DXB可使组织胺引起的饮水抑制80%。组织胺H_2受体阻断剂甲氰咪胍(C)亦有显著的抑制作用(P<0.05),其有效剂量为32～100mg/
F.S Kraly, Colgate University, New York, New York, recently reported that both histamine and insulin can stimulate drinking water, which can be blocked by histamine receptor (H_1 or H_2) blockers. Histamine subcutaneously injected into rats significantly stimulated drinking water and showed a dose-response relationship at a dose range of 1.25-20 mg / kg. The dose of histamine that produced the maximal drinking water response was 20 mg / kg. Rats were injected intraperitoneally with dexbrompheniramine (DXB), a histamine H 1 receptor blocker, 10 min prior to histamine injection, to significantly inhibit histamine-stimulated drinking water at 20 mg / kg (P <0.001). In DXB2 ~ 16mg / kg range, with the dose increased, the inhibitory effect strengthened. DXB at 16 mg / kg inhibits histamine-induced drinking water by 80%. Histamine H_2 receptor blocker cimetidine (C) also had a significant inhibitory effect (P <0.05), the effective dose of 32 ~ 100mg /