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目的探讨妊娠期高血压疾病患者脑钠肽(BNP)、尿酸水平检测及其临床意义。方法随机选取本院确诊的妊娠期高血压疾病患者100例为研究组,同期选取正常妊娠者60例为对照组,检测2组血清BNP和尿酸水平,并分析2者与妊娠期高血压疾病的关系。结果研究组血清尿酸和BNP水平分别为(476±30.41)μmol/L和(261.32±33.58)pg/L,均明显高于对照组,差异有统计学意义(P<0.05),其中妊娠期高血压患者血清BNP水平与患者平均动脉压(MAP)水平呈明显相关(P<0.05),但尿酸水平与MAP无明显相关性(P>0.05)结论脑钠肽和尿酸水平均可能参与了妊娠期高血压疾病的发生发展,其中脑钠肽可以作为预测妊娠期高血压病情发展的临床指标之一。
Objective To investigate the levels of brain natriuretic peptide (BNP) and uric acid in patients with gestational hypertension and its clinical significance. Methods 100 cases of hypertensive disorders of pregnancy diagnosed in our hospital were randomly selected as the study group. 60 cases of normal pregnancy were selected as the control group at the same time. Serum BNP and uric acid levels were measured in the two groups. relationship. Results The levels of serum uric acid and BNP in the study group were (476 ± 30.41) μmol / L and (261.32 ± 33.58) pg / L, respectively, which were significantly higher than those in the control group Serum BNP level was significantly correlated with mean arterial pressure (MAP) in patients with hypertension (P <0.05), but there was no significant correlation between uric acid level and MAP (P> 0.05). Conclusions Brain natriuretic peptide and uric acid levels may be involved in pregnancy Hypertensive disease development, in which brain natriuretic peptide can be used as a prediction of gestational hypertension development of clinical indicators.