NMR Study on the Solution Structure of d-TGGGT

• 作 者: 丁道远 孙红哲 姚亦明 唐雯霞 王春光 张礼和
• 机 构: State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210008, PRC,State Key La
• 出 处: Chinese Science Bulletin
• 发表日期: 1994年22期
• 关键词: conformational synthesize attachment cisplatin residue aggregation helix DNA COS

In order to study the action mechanism of cisplatin on DNA,we have used the solution-phase phosphotriester method to synthesize the oligonucleotide d-TGGGT. Prior to investigating the conformational change due to Pt(Ⅱ) attachment,the

In order to study the action mechanism of cisplatin on DNA, we have used the solution-phase phosphotriester method to synthesize the oligonucleotide d-TGGGT. Prior to investigating the conformational change due to Pt (II) attachment, the