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目的:观察脑心通联合阿司匹林对短暂性脑缺血患者疗效和对血液流变学指标的影响。方法:纳入2013年6月至2014年5月我院收治的短暂性脑缺血患者87例,按随机数字表法分为观察组43例和对照组44例。对照组给予阿司匹林进行治疗,观察组患者在对照组用药基础上加用脑心通联合治疗。观察两组患者治疗六个月后的临床疗效,治疗2个月后对两组患者血液流变学指标进行对比分析。结果:治疗后观察组总有效率为93.02%,明显高于对照组72.73%。治疗后观察组全血黏度高切和全血黏度低切水平分别为(4.52±0.25、5.46±0.44)m Pa/s,均明显低于对照组(5.20±0.41、7.01±0.52)m Pa/s。3治疗后观察组患者血浆黏度和纤维蛋白原水平分别为(1.50±0.05m Pa/s、2.62±0.32g/L),均明显低于对照组(1.69±0.08m Pa/s、3.31±0.43g/L)。4治疗后观察组血小板聚集率和红细胞比容分别为(49.72±3.01、43.04±1.14)%,均明显低于对照组(60.13±3.18、45.16±1.72)%。结论:脑心通联合阿司匹林的治疗方案可提高短暂性脑缺血患者的治疗疗效,改善患者血液流变学指标,是一种有效的治疗方法。
Objective: To observe the effect of Naoxintong combined with aspirin on patients with transient cerebral ischemia and its effect on hemorheology. Methods: Totally 87 patients with transient ischemic stroke admitted to our hospital from June 2013 to May 2014 were divided into observation group (n = 43) and control group (n = 44) according to random number table. The control group was given aspirin for treatment. Patients in the observation group were given Naoxintong combined therapy on the basis of the control group. The clinical efficacy of the two groups of patients after six months of treatment was observed. After two months of treatment, the hemorrheological parameters of the two groups were compared. Results: After treatment, the total effective rate was 93.02% in the observation group, which was significantly higher than that in the control group (72.73%). After treatment, the levels of whole blood viscosity and whole blood viscosity in the observation group were (4.52 ± 0.25,5.46 ± 0.44) mPa / s, which were significantly lower than those in the control group (5.20 ± 0.41,7.01 ± 0.52) m Pa / s. 3 After treatment, the plasma viscosity and fibrinogen level in the observation group were (1.50 ± 0.05m Pa / s, 2.62 ± 0.32g / L), respectively, which were significantly lower than those in the control group (1.69 ± 0.08m Pa / s, 3.31 ± 0.43 g / L). 4 After treatment, the platelet aggregation rate and hematocrit in the observation group were (49.72 ± 3.01, 43.04 ± 1.14)%, which were significantly lower than those in the control group (60.13 ± 3.18, 45.16 ± 1.72)%. Conclusion: The combination of Naoxintong and aspirin can improve the curative effect of patients with transient cerebral ischemia and improve the indexes of hemorheology in patients with transient ischemic attack, which is an effective treatment.