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目的探讨新柏氏液基细胞学检测（thinPrep cytologic test，TCT）联合细胞DNA定量检测在宫颈病变筛查中的应用价值。方法收集2013年1月~2014年4月在大连市中心医院门诊进行妇科检查的样本2837例。对DNA定量检测阳性人群进行新柏氏液基细胞学检测，并以活检组织病理学诊断结果作为金标准，分析两种技术在宫颈病变筛查中的应用价值。结果 TCT检测的阳性率为2.64%，DNA检测阳性率为5.18%，其敏感性明显高于人工阅片。 TCT诊断结果与病理组织学诊断结果的符合率为59.09%（26/44），细胞DNA定量检测结果与病理组织学诊断结果的符合率为61.36%(27/44)。结论 TCT联合细胞DNA检测在一定程度上提高了阅片的效率，并且增加了异常细胞的检出率，从而降低了假阴性率。“,”Objective To investigate the value of ThinPrep cytologic test and cel DNA quantitative detection techonology application in screening of cervical lesions. Methods Col ected 2837 cases between January 2013 and April 2014 in dalian municipal central hospital outpatient.Use TCT test the DNA quantitative detection positive people,and with biopsy histopathology diagnosis as the gold standard, analysis the value of two kinds of techonology applition in screening of cervical lesions. Results TCT detection positive rate was 2.64%, DNA test positive rate was 5.18%, the sensitivity was significantly higher than artificial reading. The coincidence rate of TCT diagnosis and DNA test results respectively with pathological histology diagnosis was 59.09% and 61.36%.Conclusion TCT combined with cel DNA test imprives not only the ef iciency of reading but also the detection of abnomal cel s, thereby reduced false negativity.