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Altered metabolism in cancer was first discovered by Otto Warburg early last century.Although the Warburg Effect has been widely used in tumor detection,relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades.Genetic studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate metabolism.One emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control.
Altered metabolism in cancer was first discovered by Otto Warburg early last century. Though the Warburg Effect has been widely used in tumor detection, relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades. Genetic study have recently been made mutations in human cancer targeting multiple enzymes involved in intermediate metabolism. One emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control.