【摘 要】
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Dear Editor,More than 50 years have passed since the myxovirus resistance (MX) genes were first discovered and found to suppress infection with influenza viruse
【机 构】
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School of Life Science, Tianjin University, Tianjin 300072, China“,”Collaborative Innovation Center
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Dear Editor,More than 50 years have passed since the myxovirus resistance (MX) genes were first discovered and found to suppress infection with influenza viruses in mice (Lindenmann,1962).Like most mammals,mice carry two MX genes,MX1 and MX2,which have arisen by gene duplication;both of these genes exhibit antiviral activity against a wide range of viruses (Liu et al.,2013).Humans also have two MXgenes,encoding the MxA and MxB proteins,which are interferon-induced,dynaminlike large molecular weight guanosine triphosphatases (GTP-ases).The antiviral functions of MxA have been deeply explored:MxA can protect cells from infection by multiple groups of pathogenic DNA and RNA viruses,such as influenza A virus and hepatitis B virus (Liu et al.,2013).In contrast,Mx2,although closely related to MxA (63％ amino acid [aa] sequence identity),appears to have lost its antiviral function and has been recognized as playing other cellular roles,since it does not suppress the viruses tested (Melen et al.,1996).
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