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目的:研究叶酸(FA)、内皮素(ET-1)、同型半胱氨酸(Hcy)和血管内皮生长因子(VEGF)与妊娠高血压综合征的相关性。方法:选择2013年1月~2016年9月在我院进行诊治的妊娠高血压综合征患者80例,分为妊娠期高血压组即A组(40例)以及子痫前期、子痫组即B组(40例),60例正常晚期孕妇为C组,60例正常非孕妇为D组,分别检测各组的血浆FA、ET-1、Hcy和VEGF水平,并进行相关性分析。结果:四组间血浆FA、ET-1和Hcy水平相比,B组的血浆FA和VEGF水平最低(P<0.05),ET-1和Hcy水平最高(P<0.05);妊娠高血压综合征的妇女血浆FA和VEGF水平均低于正常晚期孕妇,ET-1和Hcy水平明显高于正常晚期孕妇(P<0.05);多因素logistic回归分析显示FA、ET-1、Hcy、VEGF水平是妊娠高血压综合征的危险因素。结论:妊娠期FA缺乏引起血浆Hcy水平的升高可能与妊娠高血压综合征的发病及病情发展有关,VEGF可能是妊娠高血压综合征发生、发展的一个重要危险因素。
Objective: To study the relationship between folic acid (FA), endothelin (ET-1), homocysteine (Hcy) and vascular endothelial growth factor (VEGF) and pregnancy induced hypertension syndrome. Methods: From January 2013 to September 2016 in our hospital for diagnosis and treatment of 80 patients with pregnancy-induced hypertension, divided into gestational hypertension group A (40 cases) and preeclampsia, eclampsia group that Group B (40 cases), 60 cases of normal late pregnant women as Group C, and 60 cases of normal non-pregnant women as Group D. Plasma levels of FA, ET-1, Hcy and VEGF in each group were measured and the correlation was analyzed. Results: The levels of plasma FA and VEGF in group B were the lowest (P <0.05), and the levels of ET-1 and Hcy were the highest in group B (P <0.05). The levels of plasma FA, ET- (P <0.05). The multivariate logistic regression analysis showed that the levels of FA, ET-1, Hcy and VEGF were significantly higher than those of normal pregnant women Hypertension syndrome risk factors. CONCLUSION: The increase of plasma Hcy levels induced by FA deficiency in pregnancy may be related to the pathogenesis and progression of pregnancy-induced hypertension syndrome. VEGF may be an important risk factor for the development of pregnancy-induced hypertension syndrome.