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作者测定了42例收缩功能正常或大致正常,舒张功能障碍性轻、中度(Ⅰ°与Ⅱ°)心衰患者血小板Ca~(2+)、红细胞Ca~(2+)及其膜Ca~(2+),Mg~(2+)-ATP酶活性。结果表明:心衰组血小板Ca~(2+)与红细胞Ca~(2+)含量升高,Ca~(2+),Mg~(2+)-ATP酶活性下降,与对照组比较,P<0.001,其巾Ⅰ°与Ⅱ°间P<0.05或<0.001;不同心脏病间,上述改变以高血压性心脏病最明显,其次为肥厚型心肌病与冠心病。提示:细胞内Ca~(2+)超负荷可能是舒张功能障碍的原因之一。
The authors determined the expressions of platelet Ca2 +, erythrocyte Ca2 + and Ca ~ (2 +) in 42 patients with normal or almost normal contractile function, mild to moderate diastolic dysfunction, (2 +), Mg ~ (2 +) - ATPase activity. The results showed that the content of Ca2 + and erythrocyte Ca2 + in heart failure group increased and the activity of Ca2 + and Mg2 + - ATPase decreased. Compared with the control group, P <0.001, the towel Ⅰ ° and Ⅱ ° P <0.05 or <0.001; different heart disease, the above changes to the most obvious hypertensive heart disease, followed by hypertrophic cardiomyopathy and coronary heart disease. Tip: intracellular Ca ~ (2 +) overload may be one of the causes of diastolic dysfunction.