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目的分析引起新生儿重症监护病房(NICU)真菌性败血症的感染因素,探讨控制感染流行的有效措施。方法回顾性分析2008年9月7-17日集中出现的感染病例,对其临床特征、病原学检查结果、侵入性治疗、原发基础疾病等进行研究,采取多科合作、启动医院感染突发事件应急预案,控制真菌性败血症感染在病室内流行。结果同期NICU内真菌性败血症感染罹患率为5.43%,真菌均为近平滑假丝酵母菌;引起感染高危因素有早产、原发疾病、免疫力低下、联合使用广谱抗菌药物、侵入性治疗等;采取对症治疗措施后,所有感染病例均痊愈,无一例死亡。结论 NICU真菌性败血症感染属局部暴发流行,早期发现、从各个环节予以分析、早期开展经验性治疗,能够有效控制感染的进一步蔓延。
Objective To analyze the factors that cause fungal sepsis in neonatal intensive care unit (NICU) and to explore effective measures to control the epidemic. Methods Retrospective analysis of September 7-17, 2008 concentrated infection cases, clinical features, etiological examination results, invasive treatment, primary underlying diseases, etc., to take multi-disciplinary cooperation to start the sudden onset of nosocomial infections Incident emergency plan to control fungal sepsis infection prevalence in the ward. Results The prevalence of fungal sepsis in NICU was 5.43% in the same period, and the fungi were Candida albicans. The high risk factors of infection were premature delivery, primary disease, low immunity, combined use of broad-spectrum antibiotics and invasive treatment After the symptomatic treatment was taken, all the infected cases were cured, and none died. Conclusion NICU fungal septicemia infection is a local outbreak, early detection, analysis from all aspects, early empirical treatment, can effectively control the further spread of infection.