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本文采用高效液相色谱法比较研究了家兔5—Fu腹腔、静脉和灌胃三种给药途径的药代动力学。结果显示：大剂量腹腔给药能在腹腔、门静脉及肝脏提供高浓度药物，且维持时间较长，消除半衰期（T分别为3．81±0．14h和1．83±0．091h，而周围血药浓度极低；静脉给药后周围血药浓度及门静脉血药浓度均较高，但有效血药浓度维持时间短，分别为0．714±0．02h和0．668±0．04h；灌胃给药后，虽然门静脉血药浓度高于周围血，但吸收不规则，个体差异较大．对组织中药物浓度测定发现；腹腔给药后，肝脏中药浓度最高，肾脏浓度最低，而静脉络药则肾脏浓度最高。这些药代动力学特点提示对胃肠道肿瘤术后腹腔内复发和肝转移的防治，腹腔化疗将远较传统的静脉化疗和口服给药为优。
In this paper, the pharmacokinetics of 5-Fu 5-Fu intraperitoneal, intravenous and intragastric administration routes were compared using high performance liquid chromatography. The results showed that: high-dose intraperitoneal administration can provide high concentrations of drugs in the abdominal cavity, portal vein and liver, and maintain a longer time, elimination half-life (T were 3.81 ± 0.14h and 1.83 ± 0.091h, while around The plasma concentration was very low; the peripheral blood concentration and portal vein blood concentration were higher after intravenous administration, but the effective plasma concentration maintenance time was short, 0.714 ± 0.02h and 0.668 ± 0.04h respectively; After intragastric administration, though the plasma concentration of portal vein was higher than that of peripheral blood, it absorbed irregularly, and there was a big difference in individuals.After intraperitoneal administration, the highest concentration of Chinese traditional medicine and the lowest concentration of kidney were found, Intravenous chemotherapy is the highest concentration of the kidney.These pharmacokinetic characteristics of gastrointestinal tumors prompted postoperative intraperitoneal recurrence and liver metastasis prevention and treatment, intraperitoneal chemotherapy will be far more than traditional intravenous chemotherapy and oral administration is excellent.