骨髓基质细胞的超微结构研究及其辐射血液学意义

• 作 者: 孙慧斌 刘及 王玉芝 陈家佩
• 机 构: 白求恩医科大学,白求恩医科大学,军事医学科学院,军事医学科学院
• 出 处: 国外医学(放射医学分册)
• 发表日期: 1984年04期
• 关键词: 辐射血液学 基质细胞 造血器官 基质祖细胞 超微结构研究 网状细胞 造血微环境 成纤维样细胞 体外培养 基质细胞集落

CFU-f(colony forming unit-fibroblastoid)或FCFC(fibroblast colony forming cell)是造血组织中具有相当增殖潜能,在维持细胞池自身恒定的同时,尚可不断分化生成各类基质细胞的原始阶段细胞。通常认为,这就是造血器官的基质祖细胞(Stromal Precursor)。体外培养中,CFU—f能够产生由成纤维样细胞(相当于体内造血器官网状细胞)、脂肪细胞、内皮细胞、巨噬细胞等组成的贴壁基质细胞集落。在骨髓或体外培养中,这些基质细胞参与造血微环境的构成,分泌基底膜蛋白(laminin)、纤维结合素

CFU-f (colony forming unit-fibroblastoid) or FCFC (fibroblast colony forming cell) is a primitive stage cell with considerable proliferation potential in hematopoietic tissue, which can continuously differentiate into various types of stromal cells while maintaining the cell pool constant. It is generally believed that this is the Stromal Precursor of hematopoietic organs. In vitro culture, CFU-f is capable of producing adherent stromal cell colonies composed of fibroblast-like cells (equivalent to reticulocytes in the body), adipocytes, endothelial cells, macrophages, and the like. In bone marrow or in vitro culture, these stromal cells are involved in the formation of the hematopoietic microenvironment, secreting laminin, fibronectin