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目的观察血必净联合纳洛酮抢救急性酒精重度中毒疗效。方法将60例急性酒精中毒的患者给予血必净50ml,加入生理盐水100ml,快速静滴,每日2次,连用7～14d,或甚至清醒后继续用药5～10d,同时首次给予纳洛酮0.4～0.8mg,静推。然后以0.4～2mg/h加入5%葡萄糖注射液持续静滴,直至清醒。同时评估多器官功能受损修复情况。对照组40例采用纳洛酮2mg加5%葡萄糖注射液500ml中,静滴,每日一次,同时给予速尿针20mg Bid iv,直至苏醒。同时评估多器官功能受损修复情况。结果治疗组60例中,有效率96%,苏醒时间最快1h,最晚28h,平均5.1h;肝肾功能明显恢复平均时间为2.3d;对照组40例中,有效率69.6%,苏醒时间最快6.9h,最晚78h,平均25.3h;肝肾功能明显恢复平均时间为4.2d;P<0.01,差异有统计学意义。结论血必净联合纳洛酮更有效缩短清醒时间,提高疗效,减少器官损伤,促进器官功能修复。
Objective To observe the effect of Xuebijing combined with naloxone in the treatment of severe acute alcohol poisoning. Methods 60 patients with acute alcoholism were given Xuebijing 50ml, 100ml normal saline, rapid intravenous infusion, twice daily, once every 7 ~ 14d, or even after awake for 5 ~ 10d, and for the first time naloxone 0.4 ~ 0.8mg, static push. Then 0.4 ~ 2mg / h by adding 5% glucose injection intravenously until awake. Simultaneous assessment of multiple organ damage repair situation. Control group, 40 cases with naloxone 2mg plus 5% glucose injection 500ml, intravenous infusion, once daily, given furosemide needle 20mg Bid iv, until awake. Simultaneous assessment of multiple organ damage repair situation. Results The treatment group of 60 cases, the effective rate of 96%, the fastest recovery time of 1h, the latest 28h, an average of 5.1h; liver and kidney function significantly restored the average time was 2.3d; control group 40 cases, the effective rate 69.6%, wake time The fastest 6.9h, the latest 78h, an average of 25.3h; liver and kidney function significantly restored the average time was 4.2d; P <0.01, the difference was statistically significant. Conclusion Xuebijing combined with naloxone is more effective in shortening the awake time, improving curative effect, reducing organ damage and promoting organ function repair.