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脆性组氨酸三联体(fragile histidine triad,FHIT)基因定位于人3号染色体短臂(3p14.2)上,许多研究表明其表达改变与人类多种肿瘤疾病关系密切。本文重点描述有关FHIT基因的分子生物学研究新进展,以及在胃癌诊治方面的意义。
Fragile histidine triad (FHIT) gene is located on the short arm of human chromosome 3 (3p14.2). Many studies have shown that its expression is closely related to many human tumor diseases. This article focuses on the recent advances in molecular biology of FHIT gene and its significance in the diagnosis and treatment of gastric cancer.