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目的 探讨子宫内膜间质肉瘤 (endometrialstromalsarcoma ,ESS)的临床病理特点 ,分析核分裂相在评价肿瘤的恶性程度与预后的意义。方法 研究 11例子宫内膜间质肉瘤临床病理特点、组织形态及免疫组化染色分析。结果 中老年多发 ,以不规则阴道出血和子宫增大为主要症状。镜下瘤组织呈浸润性生长 ,根据瘤细胞的异型性、核分裂相分为低度恶性型 (7例 )、高度恶性型 (4例 )。部分病例伴有平滑肌及性索样分化。结论 子宫内膜间质肉瘤具有多样性病理特征 ,免疫组化染色对诊断和鉴别诊断有帮助 ;瘤细胞多形性和核分裂与临床分期相结合进行预后评估
Objective To investigate the clinical and pathological features of endometrial stromal sarcoma (ESS) and to analyze the significance of mitotic phase in evaluating the malignancy and prognosis of tumors. Methods 11 cases of endometrial stromal sarcoma clinicopathological features, histological and immunohistochemical staining. The results of multiple senile, irregular vaginal bleeding and enlarged uterus as the main symptoms. Microscopic tumor tissue was invasive growth, according to the tumor atypia, mitotic phase was divided into low-grade (7 cases), high-grade (4 cases). Some cases accompanied by smooth muscle and sex cord-like differentiation. Conclusion Endometrial stromal sarcoma has a variety of pathological features, immunohistochemical staining for diagnosis and differential diagnosis; tumor cell polymorphism and mitosis and clinical staging combined prognostic assessment