Successful Treatment with Integrated Chinese and Western Medicine for Severe Overdose of Amlodipine:

• 作 者: 赖芳 张燕 谢东平 李芳 韩云
• 机 构: Intensive Care Unit,Fangcun Branch Hospital,Guangdong Provincial Hospital of Chinese Medicine,
• 出 处: Chinese Journal of Integrative Medicine
• 发表日期: 2015年09期
• 关键词: administration secretion slowly absorbed arteries dilation elimination acidosis

Introduction Amiodipine is a dihydropyridine calcium channel blocker(CCB)that inhibits calcium influx into cardiac,vascular smooth muscle cells,and pancreatic beta cells,leading to dilation of arteries and arterioles and reduction in insulin secretion.Oral administration of amiodipine is absorbed slowly but almost completely,with a high oral bioavailability up to 60%-80%.It has a large volume of distribution(21 L/kg)and a long elimination phase(t_(1/2)35-48 h).~(1-3))Severe amiodipine

Introduction Amiodipine is a dihydropyridine calcium channel blocker (CCB) that inhibits calcium influx into cardiac, vascular smooth muscle cells, and pancreatic beta cells, leading to dilation of arteries and arterioles and reduction in insulin secretion. Oral administration of amiodipine is absorbed slowly but almost completely with a high oral bioavailability up to 60% -80% .It has a large volume of distribution (21 L / kg) and a long elimination phase (t_ (1/2) 35-48 h) 3)) Severe amiodipine