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目的观察氯吡格雷联合丹参酮ⅡA磺酸钠注射液对急性脑梗死患者的疗效。方法选取2012年7月至2014年7月收治的106例急性脑梗死患者为研究对象,临床采用随机、平行对照临床试验设计方案,分为治疗组53例和对照组53例,两组均接受常规基础治疗,对照组在常规治疗基础上接受氯吡格雷治疗,治疗组在对照组的基础上加用丹参酮ⅡA磺酸钠注射液治疗,疗程为14 d。比较两组患者治疗前后的神经功能缺损程度(NIHSS)评分、日常生活活动量表(ADL)评分及临床综合疗效。结果 NIHSS评分比较:治疗组治疗后[(5.06±6.41)分]较治疗前[(12.08±6.03)分]明显下降(Z=6.002,P<0.01);对照组治疗后(7.91±7.86)分]较治疗前[(11.19±5.41)分]明显下降(Z=3.714,P<0.05);且治疗后治疗组NIHSS评分明显低于对照组(Z=2.411,P<0.05)。临床疗效评定:治疗组总有效率为90.57%;对照组总有效率为75.47%,治疗组明显高于对照组(P<0.05)。ADL评分比较:治疗后治疗组为(22.57±9.18)分,对照组为(27.55±10.58)分,治疗组明显低于对照组(P<0.05)。结论氯吡格雷联合丹参酮ⅡA磺酸钠注射液治疗急性脑梗死具有显著临床疗效,能有效改善脑梗死患者的神经功能缺损症状,提高患者的日常生活能力水平。
Objective To observe the effect of clopidogrel combined with tanshinone Ⅱ A sodium sulfonate on patients with acute cerebral infarction. Methods A total of 106 patients with acute cerebral infarction who were treated from July 2012 to July 2014 were selected as the research object. The randomized, parallel controlled clinical trial design was adopted and divided into treatment group (n = 53) and control group (n = 53) The control group received clopidogrel on the basis of conventional treatment. The treatment group was treated with sodium tanshinone Ⅱ A sulfonate injection on the basis of the control group, and the course of treatment was 14 days. The NIHSS score, ADL score and clinical efficacy were compared between the two groups before and after treatment. Results The NIHSS score of the treatment group was significantly lower than that before treatment [(5.06 ± 6.41) vs [12.08 ± 6.03] points before treatment (Z = 6.002, P <0.01; ] (P <0.05). The NIHSS score of the treatment group was significantly lower than that of the control group (Z = 2.411, P <0.05). Clinical evaluation: The total effective rate of the treatment group was 90.57%; the total effective rate of the control group was 75.47%, the treatment group was significantly higher than the control group (P <0.05). ADL score: the treatment group was (22.57 ± 9.18) points, the control group was (27.55 ± 10.58) points, the treatment group was significantly lower than the control group (P <0.05). Conclusion Clopidogrel combined with sodium tanshinone Ⅱ A sodium sulfonate has significant clinical curative effect in acute cerebral infarction. It can effectively improve the symptoms of neurological deficits in patients with cerebral infarction and improve their daily living ability.