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目的：探讨原发性甲状腺鳞癌的临床病理特点。方法：回顾性分析两院33年来收治的8例原发性甲状腺鳞癌、结果：8例中2例为30岁以下的年轻人。甲状腺鳞癌恶性度高，获随访的7例中1例已无瘤生存14年，另1例治疗期间因肿块侵及颈鞘致大出血而院内死亡。余5例存活仅2～9个月。结论;甲状腺鳞癌可从甲状腺良、恶性病变中演变而来，病理上可表现为良、恶性病变与鳞癌变及间变状态并存。病理中存在鳞状化生，应作为鳞癌处理。
Objective: To investigate the clinicopathological features of primary thyroid squamous cell carcinoma. METHODS: A retrospective analysis of 8 cases of primary thyroid squamous cell carcinoma treated in both hospitals for 33 years was performed. Outcome: 2 out of 8 cases were young people under 30 years of age. The thyroid squamous cell carcinoma was highly malignant. One of the 7 cases that had been followed up had survived without a tumor for 14 years. The other patient died of in-hospital death due to massive invasion of the neck and sheath during treatment. The remaining 5 cases survived only 2 to 9 months. Conclusion: Thyroid squamous cell carcinoma can be evolved from benign and malignant thyroid lesions. Pathologically, it can be characterized by benign and malignant lesions coexisting with squamous cell carcinoma and metamorphosis. Squamous metaplasia exists in pathology and should be treated as squamous cell carcinoma.