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近红外荧光断层成像使用分子荧光标记物,应用在早期癌症诊断上。灵活的三维荧光断层分子成像被证明可以很好地用于临床小鼠实验上。该分子成像方法由激光器、一个可以调节增益的CCD相机组成,采用卡尔曼滤波重建算法,使用荧光试剂进行小鼠肿瘤的荧光监测。ICG可以标记肿瘤的位置,采用Toast断层成像算法用来得到三维的ICG分布图,这样小鼠肿瘤可以精确地被重建。
Near infrared fluorescence tomography using molecular fluorescent markers, used in early cancer diagnosis. Flexible three-dimensional fluorescence tomography molecular imaging has proved to be very useful in clinical mouse experiments. The molecular imaging method consists of a laser, a CCD camera with adjustable gain, a Kalman filter reconstruction algorithm and fluorescence detection of mouse tumors using fluorescent reagents. The ICG can mark the location of the tumor and use the Toast tomography algorithm to obtain a three-dimensional ICG profile so that the mouse tumor can be accurately reconstructed.