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目的:分析利奈唑胺对肾功能不全G+患者血小板减少的关系。方法:回顾性分析92例应用利奈唑胺治疗的革兰阳性球菌感染患者的临床资料,根据是否伴有肾功能不全分为肾功能不全组(33例),正常组(59例),检测用药前、用药后血小板计数,观察停药后血小板计数恢复正常时间及不良反应发生情况。结果:肾功能不全组治疗后血小板计数显著低于治疗前及正常组(P<0.01),正常组治疗前、后血小板计数比较无统计学意义(P>0.05);肾功能不全组血小板减少发生率高于正常组(P<0.05);停药后正常组血小板恢复正常时间短于肾功能不全组(P<0.01);肾功能不全组血红蛋白下降率高于正常组(P<0.05),其余不良反应发生率比较差异无统计学意义(P>0.05)。结论:感染患者肾功能可影响利奈唑胺所致血小板减少发生率,肾功能不全患者在应用利奈唑胺时应定期监测血小板计数。
Objective: To analyze the relationship between linezolid and thrombocytopenia in patients with renal insufficiency G +. Methods: The clinical data of 92 patients with gram-positive cocci infection treated with linezolid were retrospectively analyzed. According to their renal insufficiency, they were divided into renal dysfunction group (n = 33) and normal group (n = 59) Before and after administration of platelet count, observed after stopping platelet count returned to normal time and adverse reactions. Results: The platelet counts of patients with renal dysfunction group were significantly lower than those before and after treatment (P <0.01), and there was no significant difference in platelet count before and after treatment between two groups (P> 0.05). The incidence of thrombocytopenia in patients with renal insufficiency (P <0.05). The platelet recovery time of the normal group was shorter than that of the renal insufficiency group (P <0.01) after stopping the drug treatment. The decrease rate of hemoglobin in the renal dysfunction group was higher than that of the normal group (P <0.05) The incidence of adverse reactions was no significant difference (P> 0.05). CONCLUSIONS: Renal function in infected patients can affect the incidence of linezolid-induced thrombocytopenia. Patients with renal insufficiency should be regularly monitored for platelet counts when linezolid is administered.