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本文综述了近年来药物体内氧化代谢与遗传关系的研究进展。介绍了氧化代谢(如同乙酰化代谢一样)存在着个体差异和人种差异的情况。叙述了研究方法以及与新药发展和药物临床应用的关系。 近二十多年来,遗传因素引起机体对药物反应的差异已引起人们的重视。遗传因素决定机体对药物的反应主要表现在对药代动力学的影响,其次也表现在对药效动力学的影响,这
This review summarizes recent advances in the study of the relationship between oxidative metabolism and genetic in vivo. The case of oxidative metabolism (as with acetylated metabolism) is described as having individual and ethnic differences. Describes the research methods and the relationship between the development of new drugs and the clinical application of drugs. Nearly two decades, the genetic factors that cause the body’s response to drugs has drawn people’s attention. Genetic factors determine the body’s response to the drug is mainly reflected in the pharmacokinetics, followed by performance pharmacodynamics, which