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目的：探讨2型糖尿病肾脏早期损伤的实验室诊断指标。方法：分析92例2型糖尿病患者24小时尿液中的微量白蛋白(MALB/24H)、al-微球蛋白(α1MG/24H)，尿N-乙酰-β-D氨基葡萄糖苷酶（NAG/24H）、尿肌肝（CR/24H）、尿尿素氮（BUN/24H）、尿尿酸（UA/24H）和血清胱抑素C（CYS-C）的水平。根据MALB/24H水平和临床蛋白尿及血肌酐将患者分为4组：无DN组、DNⅡ组、DNⅢ组、DNⅣ组。结果：DNⅡ组MALB/24H、α1MG/24H较无DN组高（P<0.05）,并且下一组比上一组水平高（P<0.05）,NAG/24H和CYS-CDNⅥ组水平比无DN组、DNⅡ组和DNⅢ组高（P<0.05），而CR/24H、BUN/24H和UA/24H各组间差别无统计学意义。联合检测有利于DN的早期诊断。“,”Objective Toclarify the value of urineMALB/24H,α1MG/24H ,NAG/24H,CR/24H,BUN/24H,UA/24H and serum CYS-C for therelrlydiagnasisof type 2DN.Methods The level of urineMALB/24H,α1MG/24H ,NAG/24H,CR/24H,BUN/24H,UA/24H and serum CYS-Cwer measured and analysed in 92 type 2 diabetic patients.the patient sweredevided to group without DN ,DNⅡ,DNⅢand group DNⅣaccording the level of Umalb/24H.compared the level of urineα1MG/24H ,NAG/24H,CR/24H,BUN/24H,UA/24H and serum CYS-C.Rsults The level of urineα1MG/24H in group DNⅡwere higher than that in group without DN(P<0.05),andthe level of next group were higher than that up group(P<0.05);the level of urine NAG/24H and CYS-C in group DNⅣwere higher than that in groupDNⅢ、DNⅡ、and group without DN.Conclusion The level of MALB/24H、α1MG/24H、NAG/24H and CYS-C may be indicaors for diagnosis of early type 2 DN. Combined detection can improve the positive rate, and is valuable of clinical diagnosis.