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目的利福喷汀联合左氧氟沙星初治菌阳肺结核的临床疗效。方法选取宁夏中卫市疾病预防控制中心结核病防治科2012年2月—2014年2月收治的菌阳肺结核患者118例,按照随机数字表法将所有患者分为对照组和观察组,各59例。对照组患者采取2HRZE/4HRE治疗方案,观察组患者采取2HLZV/4HL2V治疗方案,随访6个月。观察比较两组患者的临床疗效,痰菌转阴率、病灶吸收好转及空洞愈合情况,并观察比较两组患者不良反应发生情况。结果观察组患者临床治疗总有效率高于对照组(P<0.05)。治疗后,观察组患者痰菌转阴率、病灶吸收好转率及空洞愈合率高于对照组(P<0.05)。且两组患者均未发生严重不良反应。结论利福喷汀联合左氧氟沙星初治菌阳肺结核疗效明确,可有效提高患者痰菌转阴率、病灶吸收好转率及空洞愈合率,且安全性好。
Objective Rifapentine combined with levofloxacin initial treatment of positive pulmonary tuberculosis clinical effect. Methods A total of 118 cases of bacillary positive pulmonary tuberculosis admitted from February 2012 to February 2014 in Zhongwei CDC of Ningxia were enrolled. All patients were divided into control group and observation group according to random number table. Patients in the control group were treated with 2HRZE / 4HRE, and patients in the observation group were treated with 2HLZV / 4HL2V for 6 months. The clinical efficacy, negative conversion rate of sputum bacteria, improvement of lesion absorption and cavity healing were observed and compared. The occurrence of adverse reactions in both groups were observed and compared. Results The total effective rate of clinical treatment in observation group was higher than that in control group (P <0.05). After treatment, the observation group patients with sputum negative rate, lesion recovery rate and healing rate was higher than the control group (P <0.05). And no serious adverse reactions occurred in both groups. Conclusion Rifapentin combined with levofloxacin initial treatment of positive pulmonary tuberculosis clear effect, which can effectively improve the patient’s sputum negative rate, the rate of recovery of lesions and the rate of empty healing, and good safety.