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目的 探讨血管内皮生长因子 (vascular endothelial growth factor,VEGF)在阻塞性睡眠呼吸暂停低通气综合征 (obstructive sleep apnea hypopnea syndrome,OSAHS)患者血清中的动态变化 ,讨论 VEGF动态变化的意义及与OSAHS病情的关系。方法 将 32例 OSAHS患者作为 OSAHS组 ,30例正常人为对照组 ,对所有受试对象做睡眠前 2 3:0 0和晨起 7:0 0时的血清 VEGF的含量测试 ,与对照组相比较 ,并与 OSAHS的病情进行相关性分析。结果 OSAHS患者在晨起 7:0 0时的血清 VEGF含量最高 ,明显高于对照组 ,高于睡前 2 3:0 0时血清 VEGF的含量 ,并且血清 VEGF含量与 OSAHS病情具有一定相关性。结论 OSAHS患者晨起血清 VEGF含量明显增高 ,OSAHS病情程度与 VEGF含量有密切关系 ,含量越高越重
Objective To investigate the dynamic changes of serum vascular endothelial growth factor (VEGF) in serum of patients with obstructive sleep apnea hypopnea syndrome (OSAHS), discuss the significance of the dynamic changes of VEGF and OSAHS Relationship. Methods 32 patients with OSAHS as OSAHS group and 30 normal people as control group, all subjects were tested before going to sleep at 23:00 and early morning 7:00 when the serum VEGF levels compared with the control group , And correlated with OSAHS’s condition. Results The OSAHS patients had the highest serum VEGF level at 7:00 in the morning, which was significantly higher than that of the control group, higher than the level of serum VEGF at 23:00 before bedtime, and the serum VEGF level had a certain correlation with the OSAHS. Conclusions Early morning serum VEGF levels in patients with OSAHS are significantly higher. The severity of OSAHS is closely related to the content of VEGF.